The rebound phenomenon in acute rheumatic fever.

Children suffering from acute rheumatic fever are usually treated with the hormone preparations, cortisone and A.C.T.H., or with salicylates. Almost always symptoms are rapidly alleviated and clinical signs of activity subside. In a number of cases discontinuance of treatment when the disease process seems to be quiescent is followed by an apparent recrudescence. This feature has become known as the rebound phenomenon but an extensive search of the literature has failed to reveal any detailed study of it.